are being treated for urinary incontinence and have symptoms of a urinary tract infection (UTI) or problems emptying your bladder on your own. Symptoms of a urinary tract infection may include pain or burning with urination, frequent urination, or fever
1)]. Deaths as a complication of severe dysphagia have been reported after treatment with botulinum toxin. Dysphagia may persist for several months, and require use of a feeding tube to maintain adequate nutrition and hydration. Aspiration may result from severe dysphagia and is a particular risk when treating patients in whom swallowing or respiratory function is already compromised.
Please see the Patient Information Guide available at for list of these events. Tell your health care provider about any side effects that bother you or do not go away.
Botox and Botox Cosmetic are purified forms of botulinum toxin that when injected in tiny, controlled doses are very safe and effective at relaxing excessive muscle contraction, even though ingestion of food contaminated with C. botulinum causes botulism - an often fatal, paralytic-type illness.
Botox works by interrupting the signal between nerves and muscles. Therefore, it takes some time for Botox to fully attach to the nerve endings and effectively block the release of the chemical messenger (acetylcholine) that causes muscle contractions. Responses to Botox injections are variable, but in general:
RADIESSE® and RADIESSE® (+) Injectable Implants are FDA-approved for subdermal implantation for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. RADIESSE® is also indicated for hand augmentation to correct volume loss in the dorsum of the hands.
Your healthcare provider will follow medical condition-specific dosing and administration recommendations. In a 3-month interval, they should not exceed a total dose of:
OnabotulinumtoxinA may cause loss of strength or general muscle weakness, vision problems, or dizziness within hours to weeks of receiving Botox or Botox Cosmetic. If this happens, do not drive a car, operate machinery, or do other dangerous activities.
The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults treated for spasticity and other conditions, and particularly in those patients who have an underlying condition that would predispose them to these symptoms. In unapproved uses and in approved indications, symptoms consistent with spread of toxin effect have been reported at doses comparable to or lower than doses used to treat cervical dystonia and spasticity. Patients or caregivers should be advised to seek immediate medical care if swallowing, speech or respiratory disorders occur.
Subsequent doses for patients experiencing incomplete paralysis of the target muscle may be increased up to two-fold compared to the previously administered dose.
treat overactive bladder symptoms, such as urinary urgency, frequency, or incontinence, in adults when anticholinergics do not work well enough or cannot be taken
Reconstituted BOTOX should be clear, colorless, and free of particulate matter. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration and whenever the solution and the container permit.
Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, sculptra raised scars or if you have had any other skin treatments such as skin peels.
The safe and effective use of BOTOX depends upon proper storage of the product, selection of the correct dose, and proper reconstitution and administration techniques. An understanding of standard electromyographic techniques is also required for treatment of strabismus, upper or lower limb spasticity, and may be useful for the treatment of cervical dystonia.